Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2979147 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29791472980121975fructose-16-bisphosphatase class IIQuickGO ontologyBLASTP
29806052980781177hypothetical proteinBLASTP
29808132981211399hypothetical proteinBLASTP
298166629828351170metallo-beta-lactamase family proteinflavodoxinQuickGO ontologyBLASTP
29833832983889507hypothetical proteinBLASTP
29849412985804864nucleoside hydrolase IUNH familyQuickGO ontologyBLASTP
29858212986357537peptide deformylaseQuickGO ontologyBLASTP
29864592986575117hypothetical protein
29866672987317651V-type ATPase D subunitQuickGO ontologyBLASTP
298734629887311386V-type ATPase B subunitQuickGO ontologyBLASTP
298872429905021779V-type ATPase A subunitQuickGO ontologyBLASTP
29905162990833318V-type ATPase G subunitQuickGO ontologyBLASTP
299081729918181002V-type ATPase C subunitQuickGO ontologyBLASTP
29918332992432600V-type ATPase E subunitQuickGO ontologyBLASTP
29924712992947477V-type ATPase K subunitQuickGO ontologyBLASTP
299296029949211962V-type ATPase I subunitQuickGO ontologyBLASTP
29949082995234327putative V-type ATPase G subunitQuickGO ontologyBLASTP
299555829972431686putative B12-binding Fe-S oxidoreductaseQuickGO ontologyBLASTP
29972182997793576hypothetical proteinBLASTP
29979652998684720putative phospholipase CQuickGO ontologyBLASTP
299870629999051200hypothetical proteinBLASTP
299994430024902547calcium-translocating P-type ATPase PMCA-typeQuickGO ontologyBLASTP