Pre_GI Gene

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Host: NC_008262 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008262:1795914 Clostridium perfringens SM101, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17959141796873960teichoic acid linkage unit synthesis protein-like protein lin2663QuickGO ontologyBLASTP
17970191797585567transcriptional regulatory protein putativeQuickGO ontologyBLASTP
17977811798425645V-type ATPase D subunitQuickGO ontologyBLASTP
179842817998101383V-type ATPase B subunitQuickGO ontologyBLASTP
179980318015781776V-type ATPase A subunitQuickGO ontologyBLASTP
18015951801912318V-type ATPase G subunitQuickGO ontologyBLASTP
180189918029061008V-type ATPase C subunitQuickGO ontologyBLASTP
18029191803515597V-type ATPase E subunitQuickGO ontologyBLASTP
18035431804037495V-type ATPase K subunitQuickGO ontologyBLASTP
180409718060431947V-type ATPase I subunitQuickGO ontologyBLASTP
18060301806356327hypothetical proteinBLASTP
180663318083121680radical SAM domain proteinQuickGO ontologyBLASTP
18082121808814603hypothetical proteinBLASTP
180896118102471287hypothetical proteinBLASTP
181039418119231530stage V sporulation protein BQuickGO ontologyBLASTP
18120171812817801putative lipoproteinQuickGO ontologyBLASTP
18129271813769843hypothetical proteinBLASTP
18137811814284504ferripyochelin binding proteinQuickGO ontologyBLASTP