Pre_GI Gene

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Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:1901898 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
19018981902833936probable ribose ABC transporterQuickGO ontologyBLASTP
190284719043521506probable ribose ABC transporterQuickGO ontologyBLASTP
19044391904834396probable ribose ABC transporterQuickGO ontologyBLASTP
19048371905769933ribokinaseQuickGO ontologyBLASTP
19059101906377468polypeptide deformylaseQuickGO ontologyBLASTP
19065331907492960probable undecaprenyl-phosphate N-acetylglucosaminyltransferaseQuickGO ontologyBLASTP
19076381908204567probable transcriptional regulatorQuickGO ontologyBLASTP
19084201909064645ATP synthase subunit DQuickGO ontologyBLASTP
190906719104491383V-type ATP synthase subunit BQuickGO ontologyBLASTP
191044219122171776V-type ATP synthase subunit AQuickGO ontologyBLASTP
19122341912551318V-type ATP synthase subunit FQuickGO ontologyBLASTP
191253819135451008ATP synthase subunit CQuickGO ontologyBLASTP
19135581914154597V-type sodium ATP synthase subunit EQuickGO ontologyBLASTP
19141851914679495ATP synthase subunit KQuickGO ontologyBLASTP
191473419166801947ATP synthase subunit IQuickGO ontologyBLASTP
19166671916993327hypothetical proteinBLASTP
191727019189491680Mg-protoporphyrin IX monomethyl ester oxidative cyclaseQuickGO ontologyBLASTP
19188491919451603hypothetical proteinBLASTP
191959819208841287probable lipoproteinQuickGO ontologyBLASTP
192103219225611530stage V sporulation protein BQuickGO ontologyBLASTP
19226551923455801hypothetical proteinBLASTP
19235651924407843hypothetical proteinBLASTP