Pre_GI Gene

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Host: NC_015425 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015425:906969 Clostridium botulinum BKT015925 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9069699081921224protonglutamate symporterQuickGO ontologyBLASTP
9084169097351320hypothetical proteinBLASTP
909770910489720phospholipase C-like proteinQuickGO ontologyBLASTP
910650911177528hypothetical proteinBLASTP
9111619128671707putative B12-binding Fe-S oxidoreductaseQuickGO ontologyBLASTP
913079913405327V-type sodium ATP synthase subunit GQuickGO ontologyBLASTP
9133929153561965V-type sodium ATP synthase subunit IQuickGO ontologyBLASTP
915328915441114hypothetical protein
915445915945501V-type ATPase K subunitQuickGO ontologyBLASTP
915968916564597ATP synthase E31 kDa subunitQuickGO ontologyBLASTP
9165789175791002ATP synthase CAC39 subunitQuickGO ontologyBLASTP
917572917880309V-type ATPase G subunitQuickGO ontologyBLASTP
9179039196781776V-type ATPase subunit AQuickGO ontologyBLASTP
9196719210531383V-type ATPase subunit BQuickGO ontologyBLASTP
921056921706651V-type ATPase subunit DQuickGO ontologyBLASTP
921878922357480peptide deformylaseQuickGO ontologyBLASTP
922488922994507hypothetical proteinBLASTP
923058923396339hypothetical proteinBLASTP
9239049250911188flavodoxinQuickGO ontologyBLASTP
925664926632969fructose-16-bisphosphataseQuickGO ontologyBLASTP
926829927752924HPr kinaseQuickGO ontologyBLASTP
9277369282845495-formyltetrahydrofolate cyclo-ligaseQuickGO ontologyBLASTP
928335929276942putative divalent cation transporterQuickGO ontologyBLASTP
9293679307761410peptidase M18 aminopeptidase IQuickGO ontologyBLASTP