Pre_GI Gene

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Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:2930259 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29302592930714456S-ribosylhomocysteinase LuxSQuickGO ontologyBLASTP
29307272931614888510-methylenetetrahydrofolate reductaseQuickGO ontologyBLASTP
29320312932981951UDP-GlcNAcundecaprenyl-P GlcNAc 1-P transferaseQuickGO ontologyBLASTP
293336129351091749nucleotidaseQuickGO ontologyBLASTP
29354342936075642V-type ATPase D subunitQuickGO ontologyBLASTP
293607929374581380V-type ATPase B subunitQuickGO ontologyBLASTP
293745129392291779V-type ATPase A subunitQuickGO ontologyBLASTP
29392472939558312ATP synthase F14-kDa subunitQuickGO ontologyBLASTP
293955129405521002ATP synthase CAC39 subunitQuickGO ontologyBLASTP
29405652941155591ATP synthase E31 kDa subunitQuickGO ontologyBLASTP
29411902941675486V-type ATPase K subunitQuickGO ontologyBLASTP
294168929436231935V-type ATPase I subunitQuickGO ontologyBLASTP
29436402943966327V-type sodium ATP synthase subunit GQuickGO ontologyBLASTP
294418329458471665radical SAM domain proteinQuickGO ontologyBLASTP
29458222946385564hypothetical proteinBLASTP
294657629478801305hypothetical proteinBLASTP
294807729495761500stage V sporulation protein BQuickGO ontologyBLASTP