Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:2117207 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21172072118142936ribose ABC transporter permease proteinQuickGO ontologyBLASTP
211815621196611506ribose ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
21197492120144396ribose ABC transporter ribose-binding proteinQuickGO ontologyBLASTP
21201472121079933ribokinaseQuickGO ontologyBLASTP
21212202121687468polypeptide deformylaseQuickGO ontologyBLASTP
21218432122802960glycosyl transferase group 4 family proteinQuickGO ontologyBLASTP
21229482123514567putative transcriptional regulatory proteinQuickGO ontologyBLASTP
21237302124374645V-type ATPase D subunitQuickGO ontologyBLASTP
212437721257591383V-type ATPase B subunitQuickGO ontologyBLASTP
212575221275271776V-type ATPase A subunitQuickGO ontologyBLASTP
21275442127861318V-type ATPase G subunitQuickGO ontologyBLASTP
212784821288551008V-type ATPase C subunitQuickGO ontologyBLASTP
21288682129464597V-type ATPase E subunitQuickGO ontologyBLASTP
21294952129989495V-type ATPase K subunitQuickGO ontologyBLASTP
213004421319931950V-type ATPase I subunitQuickGO ontologyBLASTP
21319802132306327ATP synthase-like proteinQuickGO ontologyBLASTP
213258321342621680radical SAM domain proteinQuickGO ontologyBLASTP
21341622134764603hypothetical proteinBLASTP
213491121361971287hypothetical proteinBLASTP
213634521378741530stage V sporulation protein BQuickGO ontologyBLASTP
21379682138768801hypothetical proteinBLASTP
21388782139720843hypothetical proteinBLASTP
21397322140235504bacterial transferase hexpeptide repeat proteinQuickGO ontologyBLASTP