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Query: NC_010723:2735196:2744878 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2744878, End: 2745468, Length: 591

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2930259:294056529405652941155591Clostridium botulinum B str. Eklund 17B, complete genomeATP synthase (E/31 kDa) subunit3e-79293
NC_008262:1795914:180291918029191803515597Clostridium perfringens SM101, complete genomeV-type ATPase, E subunit3e-31134
NC_003366:1901898:191355819135581914154597Clostridium perfringens str. 13, complete genomeV-type sodium ATP synthase subunit E3e-31134
NC_008261:2117207:212886821288682129464597Clostridium perfringens ATCC 13124, complete genomeV-type ATPase, E subunit3e-31134
NC_012563:2979147:299183329918332992432600Clostridium botulinum A2 str. Kyoto, complete genomeV-type ATPase, E subunit9e-27119
NC_009697:2680607:269068126906812691280600Clostridium botulinum A str. ATCC 19397 chromosome, completeV-type ATPase, E subunit4e-25114
NC_008593:841291:850364850364850960597Clostridium novyi NT, complete genomeATP synthase (E/31 kDa) subunit2e-24112
NC_015425:906969:915968915968916564597Clostridium botulinum BKT015925 chromosome, complete genomeATP synthase (E/31 kDa) subunit3e-23108
NC_014538:2396559:240986824098682410470603Thermoanaerobacter sp. X513 chromosome, complete genomeH+transporting two-sector ATPase subunit E1e-1686.3
NC_010320:2397395:241070424107042411306603Thermoanaerobacter sp. X514 chromosome, complete genomeH+-transporting two-sector ATPase subunit E1e-1686.3
NC_013921:2375900:238889223888922389494603Thermoanaerobacter italicus Ab9 chromosome, complete genomeH+transporting two-sector ATPase E subunit2e-1685.5
NC_014209:2257316:227031022703102270912603Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,H+transporting two-sector ATPase E subunit2e-1685.5
NC_010321:2319820:233145223314522332054603Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeH+-transporting two-sector ATPase subunit E1e-1583.2
NC_014964:2301835:231346723134672314069603Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeH+transporting two-sector ATPase subunit E1e-1583.2
NC_013192:815854:825142825142825693552Leptotrichia buccalis DSM 1135, complete genomeH+transporting two-sector ATPase E subunit6e-1270.5
NC_017179:3222015:323262532326253233188564Clostridium difficile BI1, complete genomeV-type sodium ATP synthase subunit E1e-0756.2
NC_013315:3214063:322467332246733225236564Clostridium difficile CD196 chromosome, complete genomeV-type sodium ATP synthase subunit E1e-0756.2
NC_015216:405657:412597412597413220624Methanobacterium sp. AL-21 chromosome, complete genomeV-type proton ATPase subunit E6e-0650.8