Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_017062: Rickettsia typhi str. B9991CWPP chromosome, complete genome

NCBI: NC_017062

Host Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. R. prowazekii, and genomic comparisons demonstrate colinearity and similarity to the genome of that organism except for two independent inversions near the origin and terminus. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
133268*5414520878Island text1.6333816.979922.2622Neighbours21BLASTN+33268.gbk
261500*8400522506Island text2.8626514.223626.2422Neighbours21BLASTN+61500.gbk
3141270*18486743598Island text1.8542214.70623.5507Neighbours21BLASTN+141270.gbk
4244330*26276818439Island text1.7242212.177817.5783Neighbours21BLASTN+244330.gbk
5508500*52746218963Island text1.793412.147417.9011Neighbours21BLASTN508500.gbk
6547317*57011222796Island text1.3970214.56124.3087Neighbours21BLASTN547317.gbk
7685321*70572020400Island text1.9472612.247721.9028Neighbours21BLASTN685321.gbk
8812133*83910926977Island text1.9001314.102626.1395Neighbours21BLASTN812133.gbk
9996197*102362627430Island text1.8949315.88225.3242Neighbours21BLASTN996197.gbk