Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_016516: Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete

NCBI: NC_016516

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
1151024157626475Island text1.6211126.864732.8536Neighbours11BLASTN+15102.gbk
230084631964618801Island text1.67122.540737.9522Neighbours11BLASTN300846.gbk
3463460*48702923570Island text1.4887324.331246.3942Neighbours11BLASTN+463460.gbk
4834260*87011135852Island text2.7123627.565750.7808Neighbours11BLASTN+834260.gbk
51203000122684223843Island text1.962528.459146.914Neighbours11BLASTN1203000.gbk
61345840*136933423495Island text1.8501825.787841.2646BLASTN+1345840.gbk
71751336*177528523950Island text2.4529531.567738.9481Neighbours11BLASTN+1751336.gbk
81799521182263723117Island text2.2148330.517551.072Neighbours11BLASTN+1799521.gbk
92314115*234059926485Island text1.6605723.902635.6316Neighbours11BLASTN+2314115.gbk
102380131240287922749Island text1.5221425.418837.6616Neighbours11BLASTN+2380131.gbk
112473500*249849925000Island text1.557625.620141.0038Neighbours11BLASTN2473500.gbk