Pre_GI Gene

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Host: NC_016516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016516:1203000 Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
120309912051382040beta-lactamaseQuickGO ontologyBLASTP
12052371205884648hypothetical proteinBLASTP
12058941206766873transcriptional regulatorQuickGO ontologyBLASTP
12068921207806915N-acetylmuramic acid 6-phosphate etheraseQuickGO ontologyBLASTP
120782612093431518phosphotransferase system EIICQuickGO ontologyBLASTP
12093471209793447hypothetical proteinBLASTP
12097831210718936BadFBadGBcrABcrD ATPase family proteinQuickGO ontologyBLASTP
121071512117251011Tat twin-arginine translocation pathway signal sequenceQuickGO ontologyBLASTP
121172212131521431glycosyl hydrolase family proteinQuickGO ontologyBLASTP
12131801213491312PTS system LactoseCellobiose specific IIB subunitQuickGO ontologyBLASTP
121348812147651278putative PTS system cellobiose-specific IIC componentQuickGO ontologyBLASTP
12147621215127366PTS system LactoseCellobiose specific IIA subunitQuickGO ontologyBLASTP
121609212196643573DNA polymerase III subunit alphaQuickGO ontologyBLASTP
12196611220215555hypothetical proteinBLASTP
122023812215391302bifunctional histidinal dehydrogenase histidinol dehydrogenaseQuickGO ontologyBLASTP
122153612227021167histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
12226991223319621imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
12233121223929618imidazole glycerol phosphate synthase glutamine amidotransferase subunitQuickGO ontologyBLASTP
12239421224709768phosphoribosyl isomerase AQuickGO ontologyBLASTP
12248591225653795hypothetical proteinBLASTP
12256501226240591Crossover junction endodeoxyribonuclease RuvCQuickGO ontologyBLASTP
12262371226842606Holliday junction DNA helicase RuvAQuickGO ontologyBLASTP