Pre_GI Gene

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Host: NC_016516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016516:1751336 Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
175133617524901155UDP-N-acetylmuramyl tripeptide synthase Mur ligaseQuickGO ontologyBLASTP
17524871753215729CobBCobQ-like proteinQuickGO ontologyBLASTP
1753272175334776tRNA-LysQuickGO ontology
175360517549181314extracellular solute-binding proteinQuickGO ontologyBLASTP
175502817560681041binding-protein-dependent transport system inner membrane proteinQuickGO ontologyBLASTP
17560651756946882binding-protein-dependent transport system inner membrane proteinQuickGO ontologyBLASTP
17570201757586567hypothetical proteinBLASTP
17576701758155486peroxiredoxin AhpCTSA family proteinQuickGO ontologyBLASTP
1758206175829085tRNA-LeuQuickGO ontologyBLASTP
17587361759569834lysozyme M1QuickGO ontologyBLASTP
17599621760240279hypothetical proteinBLASTP
17604371760601165adhesion protein-associated proteinQuickGO ontology
17606251761014390adhesion protein-associated proteinQuickGO ontologyBLASTP
176101117622941284thrombospondin type 3 repeat proteinQuickGO ontologyBLASTP
17623191763194876hypothetical proteinBLASTP
17635731763935363hypothetical protein
17641071764895789RpiR family transcriptional regulatorQuickGO ontologyBLASTP
176549217671801689membrane-spanning proteinQuickGO ontologyBLASTP
176723317686301398DNA polymerase IVQuickGO ontologyBLASTP
17686271769097471dihydrofolate reductaseQuickGO ontologyBLASTP
17691411769953813thymidylate synthaseQuickGO ontologyBLASTP
17699541770556603nucleoside-triphosphataseQuickGO ontologyBLASTP
17705651771329765ribonuclease PHQuickGO ontologyBLASTP
17713631772217855glutamate racemaseQuickGO ontologyBLASTP
17724011772718318ferrous iron transport protein AQuickGO ontologyBLASTP
177285717747431887ferrous iron transport protein BQuickGO ontologyBLASTP
17747431775285543hypothetical proteinBLASTP