Pre_GI Gene

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Host: NC_016516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016516:2380131 Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
238013123822002070NAD synthetaseQuickGO ontologyBLASTP
2382379238462522476-phosphofructokinaseQuickGO ontologyBLASTP
238469223858041113alanine dehydrogenaseQuickGO ontologyBLASTP
238609123875901500D-serineD-alanineglycine transporterQuickGO ontologyBLASTP
23879112388375465hypothetical protein
23885412388672132hypothetical proteinBLASTP
238889623901071212secreted lipoproteinQuickGO ontologyBLASTP
239037823918441467lipoproteinQuickGO ontologyBLASTP
239213923934251287citrate Si-synthaseQuickGO ontologyBLASTP
239366423946891026adenosine deaminaseQuickGO ontologyBLASTP
239473623958481113alanine dehydrogenaseQuickGO ontologyBLASTP
23960222396537516AsnC family transcriptional regulatorQuickGO ontologyBLASTP
23968222397088267hypothetical proteinBLASTP
239732223983651044dihydrodipicolinate reductaseQuickGO ontologyBLASTP
23983772398724348hypothetical proteinBLASTP
239872124001421422threonine synthase cystathionine beta-synthaseQuickGO ontologyBLASTP
24001422400564423hypothetical proteinBLASTP
240056124028792319D-ornithine aminomutase E componentQuickGO ontologyBLASTP