Pre_GI Gene

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Host: NC_016516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016516:300846 Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3008463022191374D-alanyl-D-alanine carboxypeptidaseD-alanyl-D-alanine-endopeptidaseQuickGO ontologyBLASTP
302219303154936hypothetical proteinBLASTP
303182303736555hypoxanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
3038783060312154cell division protein FtsHQuickGO ontologyBLASTP
306102306671570GTP cyclohydrolase IQuickGO ontologyBLASTP
306744307037294hypothetical proteinBLASTP
3072793083851107OmpA family proteinQuickGO ontologyBLASTP
308385309023639hypothetical proteinBLASTP
309227309751525hypothetical proteinBLASTP
310423311397975hypothetical proteinBLASTP
311540311956417hypothetical proteinBLASTP
312012312857846dihydropteroate synthaseQuickGO ontologyBLASTP
312918313280363dihydroneopterin aldolaseQuickGO ontologyBLASTP
3132773138345582-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinaseQuickGO ontologyBLASTP
313831314367537hypothetical proteinBLASTP
314456315127672hypothetical proteinBLASTP
3152043163941191NADH dehydrogenaseQuickGO ontologyBLASTP
316533316850318hypothetical proteinBLASTP
3171123196462535negative regulator of genetic competence ClpCMecBQuickGO ontologyBLASTP