Pre_GI Gene

Some Help

Host: NC_016516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016516:1799521 Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17989381799528591phosphoribosylaminoimidazole carboxylase catalytic subunitQuickGO ontologyBLASTP
179952118006931173phosphoribosylaminoimidazole carboxylase ATPase subunitQuickGO ontologyBLASTP
18008511801330480hypothetical protein
18013171802033717peptidase family S51QuickGO ontologyBLASTP
18020811802920840bifunctional biotin--acetyl-CoA-carboxylase synthetasebiotin operon repressorQuickGO ontologyBLASTP
18030521803423372hypothetical proteinBLASTP
180351618050901575propionyl-CoA carboxylase subunit betaQuickGO ontologyBLASTP
18051021805317216hypothetical proteinBLASTP
18053191805960642Maf-like proteinQuickGO ontologyBLASTP
18065351806954420hypothetical proteinBLASTP
18072111807885675short chain dehydrogenaseQuickGO ontologyBLASTP
18079891808792804bifunctional hydroxy-methylpyrimidine kinase hydroxy-phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
18089121809772861hypothetical proteinBLASTP
18097511810221471dicarboxylate carrier MatC domain proteinQuickGO ontologyBLASTP
181095318122991347hypothetical proteinBLASTP
18125001813498999magnesium transport proteinQuickGO ontologyBLASTP
18134951813926432NUDIX family hydrolaseQuickGO ontologyBLASTP
181426218160311770phosphoribosylglycinamide synthetaseQuickGO ontologyBLASTP
18160581816810753hypothetical proteinBLASTP
181684918182281380flavoprotein disulfide reductaseQuickGO ontologyBLASTP
18184171819229813putative purine nucleotide phosphorylaseQuickGO ontologyBLASTP
181925618209321677phosphoglucomutasephosphomannomutase alphabetaalpha domain IIQuickGO ontologyBLASTP
182096418226371674AMP-binding proteinQuickGO ontologyBLASTP