Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:2101515 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
210151521026451131site-specific recombinaseQuickGO ontologyBLASTP
210279821038021005general secretion pathway proteinQuickGO ontologyBLASTP
21039472104681735general secretion pathway protein EQuickGO ontologyBLASTP
21053432106218876hypothetical proteinBLASTP
21061872107176990hypothetical proteinBLASTP
21074062108230825autolytic lysozyme 14-beta-N-acetylmuramidaseAutolysinQuickGO ontologyBLASTP
21082702108689420toxin secretionphage lysis holinQuickGO ontologyBLASTP
21087702108910141hypothetical protein
21089122109106195hypothetical protein
210912621117952670hypothetical proteinBLASTP
211179721131611365hypothetical proteinBLASTP
211317721148591683phage endopeptidaseQuickGO ontologyBLASTP
21148442115521678putative phage tail proteinQuickGO ontologyBLASTP
211552121181902670phage proteinQuickGO ontologyBLASTP
21182402118392153hypothetical proteinBLASTP
21184222118907486hypothetical proteinBLASTP
21189642119557594putative protein gp15QuickGO ontologyBLASTP
21195572119901345hypothetical proteinBLASTP
21199012120410510hypothetical proteinBLASTP
21204112120845435hypothetical proteinBLASTP
21208422121186345hypothetical proteinBLASTP
21211862121596411hypothetical proteinBLASTP
21215982121858261hypothetical proteinBLASTP
21219042122875972prophage LambdaCh01 coat proteinQuickGO ontologyBLASTP
21228952123527633hypothetical proteinBLASTP
21237962124404609hypothetical proteinBLASTP
21246132125335723hypothetical proteinBLASTP
212533521266031269phage portal protein SPP1 familyQuickGO ontologyBLASTP
212660721284031797hypothetical proteinBLASTP
212848621295291044hypothetical protein