Pre_GI: BLASTP Hits

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Query: NC_010520:2101515:2108270 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2108270, End: 2108689, Length: 420

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011898:3367457:337551233755123375928417Clostridium cellulolyticum H10, complete genometoxin secretion/phage lysis holin9e-1992
NC_014828:1987487:199063319906331991046414Ethanoligenens harbinense YUAN-3 chromosome, complete genometoxin secretion/phage lysis holin5e-1786.3
NC_013411:597235:632070632070632483414Geobacillus sp. Y412MC61, complete genometoxin secretion/phage lysis holin4e-1580.1
NC_014915:2963500:297145229714522971865414Geobacillus sp. Y412MC52 chromosome, complete genometoxin secretion/phage lysis holin4e-1580.1
NC_015697:506494:529966529966530388423Lactobacillus reuteri SD2112 chromosome, complete genomeholin6e-1579.3
NC_009633:4097536:410966841096684110084417Alkaliphilus metalliredigens QYMF chromosome, complete genometoxin secretion/phage lysis holin7e-1579.3
NC_014393:4775452:478773647877364788146411Clostridium cellulovorans 743B chromosome, complete genometoxin secretion/phage lysis holin8e-1579
NC_014538:1598106:160583816058381606248411Thermoanaerobacter sp. X513 chromosome, complete genometoxin secretion/phage lysis holin1e-1478.2
NC_010320:1268355:130813313081331308543411Thermoanaerobacter sp. X514 chromosome, complete genometoxin secretion/phage lysis holin1e-1478.2
NC_008530:1454118:147817714781771478719543Lactobacillus gasseri ATCC 33323, complete genomePhage-related holin8e-1475.9
NC_015519:2489728:250506925050692505479411Tepidanaerobacter sp. Re1 chromosome, complete genometoxin secretion/phage lysis holin8e-1475.5
NC_007432:654904:696631696631697029399Streptococcus agalactiae A909, complete genomeprophage LambdaSa04, holin1e-1375.1
NC_010337:2793667:282029628202962820709414Heliobacterium modesticaldum Ice1, complete genomeholin, toxin secretion/phage lysis family protein1e-1374.7
NC_015697:468234:489539489539489952414Lactobacillus reuteri SD2112 chromosome, complete genomeholin3e-1373.9
NC_021184:4493440:451625145162514516661411Desulfotomaculum gibsoniae DSM 7213, complete genometoxin secretion/phage lysis holin2e-1373.9
NC_016791:4038069:404680440468044047244441Clostridium sp. BNL1100 chromosome, complete genometoxin secretion/phage lysis holin4e-1373.6
NC_009328:293000:361435361435361845411Geobacillus thermodenitrificans NG80-2 chromosome, complete genomePhage tail-host specificity protein4e-1373.2
NC_016627:4323370:433270143327014333120420Clostridium clariflavum DSM 19732 chromosome, complete genomeholin, Cph1 family9e-1372
NC_016627:4270949:429324942932494293668420Clostridium clariflavum DSM 19732 chromosome, complete genometoxin secretion/phage lysis holin1e-1272
NC_010184:3464707:347056534705653470990426Bacillus weihenstephanensis KBAB4, complete genometoxin secretion/phage lysis holin2e-1271.2
NC_009012:1934107:194183819418381942257420Clostridium thermocellum ATCC 27405, complete genometoxin secretion/phage lysis holin2e-1271.2
NC_011837:2605409:263310826331082633563456Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-1270.9
NC_014410:800500:831814831814832233420Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,toxin secretion/phage lysis holin3e-1270.9
NC_014171:2519767:253580625358062536231426Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein3e-1270.5
NC_009706:2673906:270160527016052702045441Clostridium kluyveri DSM 555 chromosome, complete genomePhage holin-like protein3e-1270.5
NC_018870:2316499:233389923338992334318420Thermacetogenium phaeum DSM 12270 chromosome, complete genometoxin secretion/phage lysis holin5e-1269.7
NC_011772:2495972:251176225117622512187426Bacillus cereus G9842, complete genomeputative prophage LambdaBa02, holin5e-1269.7
NC_010183:27107:386633866339088426Bacillus weihenstephanensis KBAB4 plasmid pBWB404, completeprophage LambdaBa02, holin, putative6e-1269.3
NC_012659:3724729:375089437508943751319426Bacillus anthracis str. A0248, complete genomeputative prophage LambdaBa02, holin8e-1268.9
NC_005945:3747652:375136737513673751792426Bacillus anthracis str. Sterne, complete genomeprophage LambdaBa02, holin, putative8e-1268.9
NC_003997:3724702:375086737508673751292426Bacillus anthracis str. Ames, complete genomeprophage LambdaBa02, holin, putative8e-1268.9
NC_007530:3749645:375099437509943751419426Bacillus anthracis str. 'Ames Ancestor', complete genomeprophage lambdaba02, holin, putative8e-1268.9
NC_010003:449192:458752458752459171420Petrotoga mobilis SJ95, complete genometoxin secretion/phage lysis holin1e-1168.6
NC_012581:755982:776470776470776895426Bacillus anthracis str. CDC 684 chromosome, complete genomeputative prophage LambdaBa01, holin1e-1168.6
NC_010001:3614314:361622336162233616636414Clostridium phytofermentans ISDg, complete genometoxin secretion/phage lysis holin2e-1168.2
NC_009674:2985878:299039429903942990834441Bacillus cytotoxicus NVH 391-98 chromosome, complete genometoxin secretion/phage lysis holin2e-1167.4
NC_010184:3631891:363558736355873636012426Bacillus weihenstephanensis KBAB4, complete genometoxin secretion/phage lysis holin3e-1167.4
NC_014246:1402500:142702814270281427582555Mobiluncus curtisii ATCC 43063 chromosome, complete genomeholin protein5e-1166.2
NC_021184:4095276:410599341059934106391399Desulfotomaculum gibsoniae DSM 7213, complete genometoxin secretion/phage lysis holin9e-1165.5
NC_021064:2001786:201523620152362015712477Propionibacterium avidum 44067, complete genomeholin protein2e-1064.7
NC_010163:614634:654237654237654665429Acholeplasma laidlawii PG-8A chromosome, complete genomephage-related holin4e-1063.5
NC_015673:1038673:106087510608751061342468Corynebacterium resistens DSM 45100 chromosome, complete genomephage protein7e-1062.8
NC_013174:2163947:217257221725722172925354Jonesia denitrificans DSM 20603, complete genometoxin secretion/phage lysis holin1e-0961.6
NC_015873:1241354:125118912511891251635447Megasphaera elsdenii DSM 20460, complete genomeprophage LambdaSa04 protein2e-0961.2
NC_014915:2963500:300715330071533007548396Geobacillus sp. Y412MC52 chromosome, complete genometoxin secretion/phage lysis holin1e-0858.5
NC_018866:1790564:180150218015021801903402Dehalobacter sp. DCA chromosome, complete genometoxin secretion/phage lysis holin6e-0856.2
NC_009699:3429817:343174934317493432165417Clostridium botulinum F str. Langeland chromosome, complete genometoxin secretion/phage lysis holin8e-0855.8
NC_017297:3428429:343036134303613430777417Clostridium botulinum F str. 230613 chromosome, complete genometoxin secretion/phage lysis holin8e-0855.8
NC_017068:1852708:187566718756671875966300Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative phage lysis holin8e-0752.4
NC_012914:1851102:185110218511021851572471Paenibacillus sp. JDR-2, complete genometoxin secretion/phage lysis holin3e-0650.4
NC_014622:3676859:367685936768593677356498Paenibacillus polymyxa SC2 chromosome, complete genometoxin secretion/phage lysis holin4e-0650.4
NC_011837:3226500:324475232447523245144393Clostridium kluyveri NBRC 12016, complete genomehypothetical protein7e-0649.3
NC_009706:3291330:331325033132503313642393Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein7e-0649.3