Pre_GI: BLASTP Hits

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Query: NC_010520:2101515:2111797 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2111797, End: 2113161, Length: 1365

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:1362218:1369943136994313717871845Clostridium novyi NT, complete genomephage pre-neck appendage-like protein2e-44180
NC_015425:1295261:1321898132189813232051308Clostridium botulinum BKT015925 chromosome, complete genomephage pre-neck appendage-like protein3e-40166
NC_009706:2003194:2003194200319420069853792Clostridium kluyveri DSM 555 chromosome, complete genomephage tail fiber protein7e-1479
NC_018664:1573925:1583711158371115870433333Clostridium acidurici 9a chromosome, complete genomeputative neuraminidase3e-0757