Pre_GI: BLASTP Hits

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Query: NC_010520:2101515:2113177 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2113177, End: 2114859, Length: 1683

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:1295261:1323547132354713252351689Clostridium botulinum BKT015925 chromosome, complete genomephage endopeptidase1e-88327
NC_008593:1362218:1367575136757513693861812Clostridium novyi NT, complete genomePhage endopeptidase5e-85315
NC_011773:549500:5586185586185610412424Bacillus cereus AH820 chromosome, complete genomephage endopeptidase5e-61236
NC_014246:1402500:1428313142831314309762664Mobiluncus curtisii ATCC 43063 chromosome, complete genomeputative phage endopeptidase5e-61235
NC_020291:795500:8255588255588276872130Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage minor structural protein2e-56221
NC_020291:1122282:1137850113785011396311782Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomephage minor structural protein2e-47190
NC_010723:2269372:2270908227090822726531746Clostridium botulinum E3 str. Alaska E43, complete genomeputative phage endopeptidase1e-44181
NC_010674:2328307:2334367233436723361091743Clostridium botulinum B str. Eklund 17B, complete genomeputative phage endopeptidase2e-43177
NC_010674:950276:9659279659279676121686Clostridium botulinum B str. Eklund 17B, complete genomeGp14 protein5e-39162
NC_008261:1787345:1791790179179017948493060Clostridium perfringens ATCC 13124, complete genomeputative phage structural protein1e-37157
NC_003212:2592600:2592600259260025947412142Listeria innocua Clip11262, complete genomehypothetical protein6e-30132
NC_008555:1204000:1237369123736912395102142Listeria welshimeri serovar 6b str. SLCC5334, complete genomephage-related structural protein6e-30132
NC_004116:1827351:1836950183695018406243675Streptococcus agalactiae 2603V/R, complete genomeprophage LambdaSa2, PblB, putative9e-1789
NC_014494:47049:4704947049561569108Streptococcus pneumoniae AP200 chromosome, complete genomePblB, putative1e-1482
NC_016791:1341858:1358944135894413607191776Clostridium sp. BNL1100 chromosome, complete genomephage minor structural protein7e-1375.9
NC_002737:533291:5605685605685627122145Streptococcus pyogenes M1 GAS, complete genomehypothetical protein1e-1275.5
NC_006086:1329915:1339940133994013420872148Streptococcus pyogenes MGAS10394, complete genomePhage endopeptidase5e-1273.2
NC_007296:1230614:1237561123756112397082148Streptococcus pyogenes MGAS6180, complete genomephage endopeptidase6e-1273.2
NC_004070:1231883:1240251124025112423952145Streptococcus pyogenes MGAS315, complete genomehypothetical protein6e-1272.8
NC_008021:531730:5614455614455635892145Streptococcus pyogenes MGAS9429, complete genomephage endopeptidase9e-1272.4
NC_008022:556457:5627225627225648662145Streptococcus pyogenes MGAS10270, complete genomephage endopeptidase9e-1272.4
NC_008024:572916:5798995798995820432145Streptococcus pyogenes MGAS10750, complete genomephage endopeptidase9e-1272.4
NC_008022:1255210:1264662126466212668062145Streptococcus pyogenes MGAS10270, complete genomephage endopeptidase9e-1272.4
NC_009332:1269000:1277102127710212792462145Streptococcus pyogenes str. Manfredo chromosome, complete genomehypothetical protein9e-1272.4
NC_012471:781063:8139308139308160712142Streptococcus equi subsp. equi 4047, complete genomephage protein2e-1171.2
NC_006086:987991:9974769974769996202145Streptococcus pyogenes MGAS10394, complete genomePhage endopeptidase3e-1170.9
NC_007432:654904:6918296918296947442916Streptococcus agalactiae A909, complete genomeprophage LambdaSa04, minor structural protein1e-1068.6
NC_003485:602640:6093496093496113251977Streptococcus pyogenes MGAS8232, complete genomehypothetical protein5e-0653.1