Pre_GI: BLASTP Hits

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Query: NC_010520:2101515:2121904 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2121904, End: 2122875, Length: 972

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010516:2305110:232360523236052324552948Clostridium botulinum B1 str. Okra, complete genomeprophage LambdaCh01, coat protein1e-56220
NC_007503:1486000:149627414962741497224951Carboxydothermus hydrogenoformans Z-2901, complete genomeprophage LambdaCh01, coat protein6e-48191
NC_010001:3614314:3629170362917036301771008Clostridium phytofermentans ISDg, complete genomephage coat protein7e-42171
NC_017297:2531750:254595625459562546921966Clostridium botulinum F str. 230613 chromosome, complete genomephage coat protein1e-41170
NC_012658:1810640:183391918339191834884966Clostridium botulinum Ba4 str. 657 chromosome, complete genomephage coat protein2e-41169
NC_014376:1472304:149759614975961498594999Clostridium saccharolyticum WM1 chromosome, complete genomephage coat protein1e-40167
NC_003210:2362306:2379418237941823804191002Listeria monocytogenes EGD-e, complete genomehypothetical protein3e-36152
NC_010609:880196:9002319002319013071077Lactobacillus reuteri JCM 1112, complete genomehypothetical protein3e-30132
NC_013198:1095591:1128000112800011290131014Lactobacillus rhamnosus GG, complete genomephage protein, minor capsid protein1e-1894
NC_014551:576000:600991600991601977987Bacillus amyloliquefaciens DSM 7, complete genomeSPP1 phage coat protein p0235e-1685.5
NC_014006:850763:8638628638628648631002Sphingobium japonicum UT26S chromosome 1, complete genomehypothetical protein2e-1377
NC_017294:115500:1383031383031393611059Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeputative prophage Lp2 protein 402e-1170.5
NC_015913:117966:1389931389931400511059Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomephage coat protein4e-1168.9
NC_013517:1501276:1505603150560315066761074Sebaldella termitidis ATCC 33386, complete genomehypothetical protein2e-1067