Pre_GI: BLASTP Hits

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Query: NC_010520:2101515:2122895 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 2122895, End: 2123527, Length: 633

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010516:2305110:232457623245762325214639Clostridium botulinum B1 str. Okra, complete genomehypothetical protein5e-54210
NC_021182:2765000:277941627794162780009594Clostridium pasteurianum BC1, complete genomehypothetical protein4e-33140
NC_014377:1227850:124779012477901248392603Thermosediminibacter oceani DSM 16646 chromosome, complete genomehypothetical protein4e-27121
NC_018867:1407163:142093714209371421521585Dehalobacter sp. CF chromosome, complete genomehypothetical protein8e-24110
NC_016641:2587000:261244226124422613059618Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein7e-2097.1
NC_020272:2748733:277736727773672777948582Bacillus amyloliquefaciens IT-45, complete genomealanyl-tRNA synthetase3e-1478.6
NC_006270:1415001:144544414454441446025582Bacillus licheniformis ATCC 14580, complete genomephage related protein2e-1375.9
NC_006322:1415863:144630614463061446887582Bacillus licheniformis ATCC 14580, complete genomehypothetical protein2e-1375.9
NC_017191:2223740:222571322257132226432720Bacillus amyloliquefaciens XH7 chromosome, complete genomeribonuclease phage-like protein2e-1169.3
NC_017188:2221705:222367822236782224397720Bacillus amyloliquefaciens TA208 chromosome, complete genomehypothetical protein2e-1169.3
NC_009641:327325:342447342447343031585Staphylococcus aureus subsp. aureus str. Newman chromosome,hypothetical protein6e-0650.8