Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:3859173 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
385917338602521080ferric enterobactin enterochelin binding proteinQuickGO ontologyBLASTP
386046438615701107adhesinQuickGO ontologyBLASTP
38615953862314720chaperoneQuickGO ontologyBLASTP
386233238648122481outer membrane usher proteinQuickGO ontologyBLASTP
38651653865674510transposaseQuickGO ontologyBLASTP
38658233866245423hypothetical proteinBLASTP
38662973867163867hypothetical proteinBLASTP
38671603868014855hypothetical proteinBLASTP
38680293868478450hypothetical proteinBLASTP
386867138699031233hypothetical proteinBLASTP
386991538712011287secretion NTP hydrolaseQuickGO ontologyBLASTP
38712613872073813hypothetical proteinBLASTP
38720703872903834hypothetical proteinBLASTP
38728873873657771hypothetical proteinBLASTP
38736543874127474hypothetical proteinBLASTP
38741113874683573hypothetical proteinBLASTP
387470838762641557hypothetical proteinBLASTP
38763613876792432TonB-complex proteinQuickGO ontologyBLASTP
387679638778571062TonB complex proteinQuickGO ontologyBLASTP
387831238795231212cystathionine beta-lyaseQuickGO ontologyBLASTP
38797163880378663hypothetical proteinBLASTP
38804703881363894AraC-type regulatory proteinQuickGO ontologyBLASTP
388176138829181158oxidoreductaseQuickGO ontologyBLASTP
38829813883190210hypothetical proteinBLASTP
38833373884170834hypothetical proteinBLASTP
38841923885004813hypothetical proteinBLASTP
388498938865361548hypothetical proteinBLASTP