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Query: NC_004088:3859173:3873654 Yersinia pestis KIM, complete genome

Start: 3873654, End: 3874127, Length: 474

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:341233:356424356424356897474Yersinia pestis A1122 chromosome, complete genomehypothetical protein7e-79292
NC_009381:522731:529966529966530439474Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein7e-79292
NC_008150:3430000:344453634445363445009474Yersinia pestis Antiqua, complete genomehypothetical protein7e-79292
NC_005810:3333000:334034733403473340820474Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein7e-79292
NC_008149:650706:657943657943658416474Yersinia pestis Nepal516, complete genomemembrane protein7e-79292
NC_010634:3905369:392389239238923924365474Yersinia pseudotuberculosis PB1/+, complete genomeTadE family protein4e-78290
NC_006155:3992818:401243540124354012908474Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein4e-78290
NC_010159:259695:274179274179274649471Yersinia pestis Angola, complete genomeTadE-like family protein4e-78289
NC_003143:741169:748405748405748875471Yersinia pestis CO92, complete genomehypothetical protein4e-78289
NC_014029:792719:799949799949800419471Yersinia pestis Z176003 chromosome, complete genomehypothetical protein4e-78289
NC_017154:734875:742111742111742581471Yersinia pestis D106004 chromosome, complete genomehypothetical protein4e-78289
NC_017160:737000:744290744290744760471Yersinia pestis D182038 chromosome, complete genomehypothetical protein4e-78289
NC_017265:3724500:373901737390173739487471Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,Flp pilus assembly membrane protein TadE1e-77287
NC_009708:692508:699798699798700268471Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeTadE-like family protein1e-77287
NC_010465:733916:740167740167740640474Yersinia pseudotuberculosis YPIII, complete genomeTadE family protein3e-76283
NC_015224:3820338:384835738483573848821465Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,putative tight adherance operon protein3e-24110
NC_008800:3955284:397009539700953970559465Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,putative tight adherance operon protein4e-24110