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Query: NC_004088:3859173:3868671 Yersinia pestis KIM, complete genome

Start: 3868671, End: 3869903, Length: 1233

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005810:3333000:3344571334457133458031233Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein0771
NC_003143:741169:7526297526297538611233Yersinia pestis CO92, complete genomehypothetical protein0771
NC_006155:3992818:4007557400755740086841128Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein0699
NC_009381:522731:5341905341905353171128Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein0699
NC_009708:692508:7040227040227051491128Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein0699
NC_014029:792719:8041738041738053001128Yersinia pestis Z176003 chromosome, complete genomehypothetical protein0699
NC_017154:734875:7463367463367474631128Yersinia pestis D106004 chromosome, complete genomehypothetical protein0699
NC_017160:737000:7485147485147496411128Yersinia pestis D182038 chromosome, complete genomehypothetical protein0699
NC_017168:341233:3515463515463526731128Yersinia pestis A1122 chromosome, complete genomepilus assembly protein CpaE0699
NC_017265:3724500:3734136373413637352631128Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,Type II/IV secretion system ATPase TadZ/CpaE,associated with Flp pilus assembly0699
NC_010634:3905369:3919018391901839201451128Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein0697
NC_010159:259695:2692982692982704251128Yersinia pestis Angola, complete genomehypothetical protein0697
NC_008150:3430000:3439658343965834407851128Yersinia pestis Antiqua, complete genomehypothetical protein0696
NC_010465:733916:7443917443917455181128Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein0689
NC_008800:3955284:3965213396521339663311119Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,putative tight adherance operon protein2e-119429
NC_008149:650706:662167662167662709543Yersinia pestis Nepal516, complete genomehypothetical protein2e-102372
NC_008149:650706:662505662505663293789Yersinia pestis Nepal516, complete genomehypothetical protein2e-89330
NC_013416:668152:6825166825166836401125Aggregatibacter actinomycetemcomitans D11S-1, complete genomeTadZ5e-53208
NC_016513:974402:9887759887759898991125Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completeflp operon protein D2e-52206
NC_012913:167034:1781321781321792531122Aggregatibacter aphrophilus NJ8700, complete genomeTadZ2e-51203
NC_002940:1065246:1066538106653810676591122Haemophilus ducreyi 35000HP, complete genomeflp operon protein D8e-44178
NC_013716:4306695:4369768436976843709011134Citrobacter rodentium ICC168, complete genomeputative tight adherence protein TadZ7e-29128