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Query: NC_004088:3859173:3865823 Yersinia pestis KIM, complete genome

Start: 3865823, End: 3866245, Length: 423

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:3724500:373118337311833731605423Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,Type IV prepilin peptidase TadV/CpaA9e-45178
NC_008150:3430000:343670534367053437127423Yersinia pestis Antiqua, complete genomehypothetical protein9e-45178
NC_008149:650706:665824665824666246423Yersinia pestis Nepal516, complete genomemembrane protein9e-45178
NC_005810:3333000:334822933482293348651423Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein9e-45178
NC_003143:741169:756287756287756709423Yersinia pestis CO92, complete genomehypothetical protein9e-45178
NC_009381:522731:537848537848538270423Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein9e-45178
NC_014029:792719:807831807831808253423Yersinia pestis Z176003 chromosome, complete genomehypothetical protein9e-45178
NC_017154:734875:749994749994750416423Yersinia pestis D106004 chromosome, complete genomehypothetical protein9e-45178
NC_017160:737000:752172752172752594423Yersinia pestis D182038 chromosome, complete genomehypothetical protein9e-45178
NC_017168:341233:348593348593349015423Yersinia pestis A1122 chromosome, complete genomehypothetical protein9e-45178
NC_009708:692508:707636707636708034399Yersinia pseudotuberculosis IP 31758 chromosome, complete genometype IV prepilin peptidase family protein6e-42169
NC_006155:3992818:400457340045734004995423Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein1e-38158
NC_010159:259695:266486266486266767282Yersinia pestis Angola, complete genometype IV prepilin peptidase family2e-38157
NC_010465:733916:748063748063748485423Yersinia pseudotuberculosis YPIII, complete genomepeptidase A24A prepilin type IV7e-38155
NC_010634:3905369:391606439160643916486423Yersinia pseudotuberculosis PB1/+, complete genomepeptidase A24A prepilin type IV3e-34143
NC_008800:3955284:396228639622863962708423Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,putative tight adherance operon protein4e-31133
NC_015224:3820338:384059638405963840982387Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,putative tight adherance operon protein1e-30131
NC_013716:4306695:437847343784734378916444Citrobacter rodentium ICC168, complete genomeputative prepilin peptidase TadV3e-1063.5
NC_002940:1065246:107040710704071070841435Haemophilus ducreyi 35000HP, complete genomeflp operon protein B1e-0961.6
NC_017328:3088907:314151631415163141983468Shigella flexneri 2002017 chromosome, complete genomeputative tight adherance operon protein6e-0959.7
NC_004337:3049118:310314931031493103616468Shigella flexneri 2a str. 301, complete genomehypothetical protein6e-0959.7
NC_013416:668152:686415686415686843429Aggregatibacter actinomycetemcomitans D11S-1, complete genomeTadV1e-0755.1
NC_012913:167034:182027182027182455429Aggregatibacter aphrophilus NJ8700, complete genomeTadV2e-0754.3
NC_016513:974402:992675992675993001327Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completeflp operon protein B1e-0651.6