Pre_GI: BLASTP Hits

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Query: NC_017355:997089:1000599 Helicobacter pylori v225d chromosome, complete genome

Start: 1000599, End: 1002263, Length: 1665

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017379:996500:99925899925810011081851Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein01040
NC_017378:986611:9893459893459904511107Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein0687
NC_000915:1044000:104871410487141049427714Helicobacter pylori 26695, complete genomehypothetical protein1e-108394
NC_012973:967380:971047971047971931885Helicobacter pylori B38 chromosome, complete genome2e-105383
NC_018939:1044000:104873210487321049427696Helicobacter pylori 26695 chromosome, complete genomehypothetical protein1e-104380
NC_017378:986611:990454990454991200747Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein1e-98360
NC_017362:992293:996466996466996900435Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein6e-74278
NC_012973:967380:970520970520970966447Helicobacter pylori B38 chromosome, complete genome4e-70266
NC_000915:453958:473368473368474066699Helicobacter pylori 26695, complete genomehypothetical protein2e-55217
NC_018939:454000:473403473403474071669Helicobacter pylori 26695 chromosome, complete genomehypothetical protein2e-55217
NC_010170:4463000:4499522449952245012851764Bordetella petrii, complete genomehypothetical protein2e-36154
NC_010002:4572573:4595113459511345961951083Delftia acidovorans SPH-1, complete genomehypothetical protein2e-32140