Pre_GI Gene

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Host: NC_017379 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017379:996500 Helicobacter pylori Puno135 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
997419998243825small-conductance mechanosensitive channel membrane proteinQuickGO ontologyBLASTP
998256998435180hypothetical proteinBLASTP
998601998702102exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
99872599881793exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
998814998930117exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
998936999049114hypothetical proteinBLASTP
99925810011081851hypothetical proteinBLASTP
100110110041723072hypothetical proteinBLASTP
100417910063802202hypothetical proteinBLASTP
100637710081581782hypothetical proteinBLASTP
10081551008685531hypothetical proteinBLASTP
100868910113852697hypothetical proteinBLASTP
101137910127311353serinethreonine kinaseQuickGO ontologyBLASTP
10127221013408687hypothetical proteinBLASTP
10134051013740336hypothetical proteinBLASTP
1013737101383599hypothetical proteinBLASTP
10138351014473639phagecolicintellurite resistance cluster protein TerYQuickGO ontologyBLASTP
101567610177152040hypothetical proteinBLASTP
10202411021110870cell division proteinQuickGO ontologyBLASTP
10211271021378252hypothetical proteinBLASTP