Pre_GI Gene

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Host: NC_018939 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_018939:454000 Helicobacter pylori 26695 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
454336454764429IS605 transposase tnpAQuickGO ontologyBLASTP
4548344561171284IS605 transposase tnpBQuickGO ontologyBLASTP
4560864571861101hypothetical proteinBLASTP
4573034593362034DNA topoisomerase I topAQuickGO ontologyBLASTP
4593394617622424VirB4-like proteinQuickGO ontologyBLASTP
461755462021267hypothetical proteinBLASTP
462022462324303hypothetical proteinBLASTP
4623214638441524hypothetical proteinBLASTP
463851464144294hypothetical proteinBLASTP
464163464942780hypothetical proteinBLASTP
4649874661321146hypothetical proteinBLASTP
4703454734103066hypothetical proteinBLASTP
473403474071669hypothetical proteinBLASTP