Pre_GI Gene

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Host: NC_000915 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000915:453958 Helicobacter pylori 26695, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was originally isolated from a patient in the United Kingdom who had gastritis before 1987, this strain has undergone repeated subculturing prior to being sequenced. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
453399453974576hypothetical proteinBLASTP
453958454323366hypothetical proteinBLASTP
454330454758429IS605 transposase tnpAQuickGO ontologyBLASTP
4548284561111284IS605 transposase tnpBQuickGO ontologyBLASTP
4560804571801101hypothetical proteinBLASTP
4572974593302034DNA topoisomerase I topAQuickGO ontologyBLASTP
4593334617562424VirB4 homologQuickGO ontologyBLASTP
461749462015267hypothetical proteinBLASTP
462016462318303hypothetical proteinBLASTP
4623154638381524hypothetical proteinBLASTP
463954464139186hypothetical proteinBLASTP
464158464937780hypothetical proteinBLASTP
4650454661271083hypothetical proteinBLASTP
466124466510387hypothetical proteinBLASTP
4667574681751419hypothetical proteinBLASTP
468172468306135hypothetical proteinBLASTP
468417468701285hypothetical proteinBLASTP
4687774703331557hypothetical proteinBLASTP
4703404734053066hypothetical proteinBLASTP
473368474066699hypothetical proteinBLASTP