Pre_GI Gene

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Host: NC_017362 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017362:992293 Helicobacter pylori Lithuania75 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9922939934501158cell division protein FtsZQuickGO ontologyBLASTP
993885993986102hypothetical protein
994018994842825mechanosensitive channel MscSQuickGO ontologyBLASTP
994914995186273hypothetical proteinBLASTP
996466996900435hypothetical proteinBLASTP
996972997208237hypothetical proteinBLASTP
9995371000253717hypothetical proteinBLASTP
100320810044191212putative serinethreonine kinaseQuickGO ontologyBLASTP
10044781005095618protein phosphatase 2 C-like protein ptc1QuickGO ontologyBLASTP
10050921005424333hypothetical proteinBLASTP
1005421100551999hypothetical proteinBLASTP
10055121006171660hypothetical proteinBLASTP
1006152100625099hypothetical protein