Pre_GI Gene

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Host: NC_000915 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000915:1044000 Helicobacter pylori 26695, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was originally isolated from a patient in the United Kingdom who had gastritis before 1987, this strain has undergone repeated subculturing prior to being sequenced. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10445521044854303conserved hypothetical secreted proteinQuickGO ontologyBLASTP
10447721045137366exonuclease VII-like protein xseAQuickGO ontologyBLASTP
104507410451911185S ribosomal RNAQuickGO ontology
10455091046204696hypothetical proteinBLASTP
10470541047878825hypothetical proteinBLASTP
10479581048065108hypothetical proteinBLASTP
10480881048411324hypothetical protein
10487141049427714hypothetical proteinBLASTP
10508121051045234hypothetical proteinBLASTP
10510521051480429IS605 transposase tnpAQuickGO ontologyBLASTP
105155010528331284IS605 transposase tnpBQuickGO ontologyBLASTP
10529271053595669hypothetical proteinBLASTP
10536001054229630hypothetical proteinBLASTP
10543761054615240hypothetical proteinBLASTP
10548151055066252hypothetical proteinBLASTP
10550381055841804hypothetical proteinBLASTP
105615810572251068integraserecombinase xerDQuickGO ontologyBLASTP
105837310601751803hypothetical proteinBLASTP
106032410616071284IS605 transposase tnpBQuickGO ontologyBLASTP
10616771062105429IS605 transposase tnpAQuickGO ontologyBLASTP
10622361062421186hypothetical proteinBLASTP
10626871063343657PARA proteinQuickGO ontologyBLASTP
10634281063712285hypothetical proteinBLASTP
106375610649401185hypothetical proteinBLASTP
106496510660771113hypothetical proteinBLASTP
10660531066874822hypothetical proteinBLASTP