Pre_GI Gene

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Host: NC_012973 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012973:967380 Helicobacter pylori B38 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
967380967676297metallopeptidaseQuickGO ontologyBLASTP
967669967923255exonuclease VII large subunitQuickGO ontologyBLASTP
968424969248825small-conductance mechanosensitive channel membrane proteinQuickGO ontologyBLASTP
969535969750216hypothetical proteinBLASTP
976664976948285hypothetical proteinBLASTP
977059977193135hypothetical proteinBLASTP
9771909807923603hypothetical proteinBLASTP
9807869821351350serinethreonine kinaseQuickGO ontologyBLASTP
982809983111303hypothetical proteinBLASTP
983229983873645hypothetical proteinBLASTP
984215984358144hypothetical protein
988415988642228hypothetical protein
9886959904101716hypothetical proteinBLASTP