Pre_GI Gene

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Host: NC_018939 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_018939:1044000 Helicobacter pylori 26695 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10443021044493192hypothetical protein
10445701044872303hypothetical proteinBLASTP
10456141046222609hypothetical proteinBLASTP
10462231046513291hypothetical protein
10466381047000363hypothetical proteinBLASTP
10470721047896825hypothetical proteinBLASTP
10479761048083108hypothetical proteinBLASTP
10481831048398216hypothetical proteinBLASTP
10485491048692144hypothetical proteinBLASTP
10487321049427696hypothetical proteinBLASTP
10508291051062234hypothetical proteinBLASTP
10510691051497429IS605 transposase tnpAQuickGO ontologyBLASTP
105156710528501284IS605 transposase tnpBQuickGO ontologyBLASTP
10529561053612657hypothetical proteinBLASTP
10548321055083252hypothetical proteinBLASTP
10550551055858804hypothetical proteinBLASTP
105617510572421068integraserecombinase xerDQuickGO ontologyBLASTP
105839110602171827relaxaseQuickGO ontologyBLASTP
106034210616251284IS605 transposase tnpBQuickGO ontologyBLASTP
10616951062123429IS605 transposase tnpAQuickGO ontologyBLASTP
10622031062439237adenine specific DNA methyltransferaseQuickGO ontologyBLASTP
10627051063361657PARA proteinQuickGO ontologyBLASTP
10634461063730285hypothetical proteinBLASTP
106377410649581185hypothetical proteinBLASTP