Pre_GI Gene

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Host: NC_017378 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017378:986611 Helicobacter pylori Puno120 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
986611987075465IS606 transposaseQuickGO ontologyBLASTP
987265987426162hypothetical proteinBLASTP
988312988491180hypothetical proteinBLASTP
988656989018363exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
989024989329306hypothetical proteinBLASTP
9893459904511107hypothetical proteinBLASTP
990454991200747hypothetical proteinBLASTP
9942389964482211hypothetical proteinBLASTP
9964459982531809hypothetical proteinBLASTP
99825010014803231hypothetical proteinBLASTP
100147410028291356serinethreonine kinaseQuickGO ontologyBLASTP
10028201003506687hypothetical proteinBLASTP
10035031003826324hypothetical proteinBLASTP
1003823100392199hypothetical proteinBLASTP
10039211004559639phagecolicintellurite resistance cluster protein TerYQuickGO ontologyBLASTP