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Query: NC_012658:2584355:2586590 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2586590, End: 2587876, Length: 1287

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2575306:2576997257699725782801284Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein0698
NC_009699:2576500:2576858257685825781411284Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein0698
NC_009698:2367171:2372489237248923737721284Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein0698
NC_009697:2394826:2400144240014424014271284Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein0698
NC_009495:2524000:2528121252812125294041284Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein0698
NC_012563:2680246:2702633270263327039161284Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein0698
NC_010516:2511035:2516343251634325176261284Clostridium botulinum B1 str. Okra, complete genomehypothetical protein0696
NC_010520:2585014:2590875259087525921581284Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein0694
NC_015947:568124:5875705875705888531284Burkholderia sp. JV3 chromosome, complete genomehypothetical protein9e-21101
NC_018870:1417851:1436979143697914383251347Thermacetogenium phaeum DSM 12270 chromosome, complete genomehypothetical protein2e-1377.8
NC_007644:626992:6969466969466984121467Moorella thermoacetica ATCC 39073, complete genomehypothetical protein4e-1066.6
NC_014721:373607:3736073736073750431437Caldicellulosiruptor kristjanssonii 177R1B chromosome, completehypothetical protein3e-0756.6
NC_015949:2101302:2123953212395321253891437Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomehypothetical protein3e-0756.6
NC_012034:438000:4411194411194423301212Anaerocellum thermophilum DSM 6725, complete genomehypothetical protein2e-0653.9
NC_014355:2775979:2788816278881627901171302Candidatus Nitrospira defluvii, complete genomeputative glycosyl transferase, family 393e-0653.5
NC_009633:337706:3413683413683427981431Alkaliphilus metalliredigens QYMF chromosome, complete genomehypothetical protein4e-0653.1