Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2575306 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
257530625764991194aspartate aminotransferaseQuickGO ontologyBLASTP
25766442577000357hypothetical proteinBLASTP
257699725782801284hypothetical proteinBLASTP
25782992579165867prenyltransferase UbiA familyQuickGO ontologyBLASTP
25793292579589261stage V sporulation protein SQuickGO ontologyBLASTP
257972825812691542HDIGHDKH domain proteinQuickGO ontologyBLASTP
258150425825621059recA proteinQuickGO ontologyBLASTP
25827102583294585CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
258327825846151338MiaB family RNA modification proteinQuickGO ontologyBLASTP
258471025869862277DNA translocase FtsKSpoIIIEQuickGO ontologyBLASTP
25874672588159693clp proteaseQuickGO ontologyBLASTP
258840725896121206aspartokinase IQuickGO ontologyBLASTP
25896282589900273YlmCYmxH family sporulation proteinQuickGO ontologyBLASTP
258997725912781302peptidase M16 familyQuickGO ontologyBLASTP