Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:2585014 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
258501425862911278tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidAQuickGO ontologyBLASTP
258634225877721431adenylosuccinate lyaseQuickGO ontologyBLASTP
25880242588245222hypothetical proteinBLASTP
25882732588530258phosphocarrier protein HPrQuickGO ontologyBLASTP
258864125898341194aspartate aminotransferaseQuickGO ontologyBLASTP
25905222590878357hypothetical proteinBLASTP
259087525921581284hypothetical proteinBLASTP
25921772593043867prenyltransferase UbiA familyQuickGO ontologyBLASTP
25932062593466261stage V sporulation protein SQuickGO ontologyBLASTP
259360525951461542HDIGHDKH domain proteinQuickGO ontologyBLASTP
259538025964471068recA proteinQuickGO ontologyBLASTP
25965862597170585CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
259715425984911338RNA modification enzyme MiaB familyQuickGO ontologyBLASTP
259858626008622277DNA translocase FtsKSpoIIIEQuickGO ontologyBLASTP
26013432602035693clp proteaseQuickGO ontologyBLASTP
260228426034891206aspartokinase IQuickGO ontologyBLASTP
26035052603777273PRC-barrel domain proteinQuickGO ontologyBLASTP
260385426051551302peptidase M16 familyQuickGO ontologyBLASTP
260533026074382109polyribonucleotide nucleotidyltransferaseQuickGO ontologyBLASTP
26077022608016315ribosomal protein S15QuickGO ontologyBLASTP
26080982609018921riboflavin biosynthesis protein RibFQuickGO ontologyBLASTP
26090312609900870tRNA pseudouridine synthase BQuickGO ontologyBLASTP
26099012610863963DHH family proteinQuickGO ontologyBLASTP
26108532611215363ribosome-binding factor AQuickGO ontologyBLASTP
261124526133112067translation initiation factor IF-2QuickGO ontologyBLASTP
26133292613643315ribosomal protein L7Ae family proteinQuickGO ontologyBLASTP
26136332613905273hypothetical proteinBLASTP
261396526153381374N utilization substance protein AQuickGO ontologyBLASTP
26153552615816462hypothetical proteinBLASTP
261612126204194299DNA polymerase III alpha subunit Gram-positive typeQuickGO ontologyBLASTP