Pre_GI Gene

Some Help

Host: NC_009697 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009697:2394826 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
239482623961031278tRNA uridine 5-carboxymethylaminomethyl modification protein GidAQuickGO ontologyBLASTP
239615423975841431adenylosuccinate lyaseQuickGO ontologyBLASTP
23978362398057222hypothetical proteinBLASTP
23980852398342258phosphocarrier protein HPrQuickGO ontologyBLASTP
239845323996461194aspartate aminotransferaseQuickGO ontologyBLASTP
23997912400147357hypothetical proteinBLASTP
240014424014271284hypothetical proteinBLASTP
24014462402312867phosphoribose diphosphatedecaprenyl-phosphate phosphoribosyltransferaseQuickGO ontologyBLASTP
24024752402735261stage V sporulation protein SQuickGO ontologyBLASTP
240287424044151542phosphodiesteraseQuickGO ontologyBLASTP
240465024057081059recombinase AQuickGO ontologyBLASTP
24058562406440585CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
240642424077611338RNA modification proteinQuickGO ontologyBLASTP
240785624101322277DNA translocase FtsKSpoIIIEQuickGO ontologyBLASTP
24106132411305693Clp proteaseQuickGO ontologyBLASTP
241155324127581206aspartate kinaseQuickGO ontologyBLASTP
24127742413046273PRC-barrel domain-containing proteinQuickGO ontologyBLASTP
241312324144241302M16 family peptidaseQuickGO ontologyBLASTP
241459924167072109polynucleotide phosphorylaseQuickGO ontologyBLASTP
2416971241728531530S ribosomal protein S15QuickGO ontologyBLASTP
24173672418287921bifunctional riboflavin kinaseFMN adenylyltransferaseQuickGO ontologyBLASTP
24183002419169870tRNA pseudouridine synthase BQuickGO ontologyBLASTP
24191702420132963DHH family proteinQuickGO ontologyBLASTP
24201222420484363ribosome-binding factor AQuickGO ontologyBLASTP
242051524225812067translation initiation factor IF-2QuickGO ontologyBLASTP
24225992422916318ribosomal protein L7Ae family proteinQuickGO ontologyBLASTP
24229032423175273hypothetical proteinBLASTP
242323524246081374transcription elongation factor NusAQuickGO ontologyBLASTP
24246252425086462hypothetical proteinBLASTP
242539124296894299DNA polymerase III PolCQuickGO ontologyBLASTP