Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2680246 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
267901826802561239phage terminase large subunit pbsx familyQuickGO ontologyBLASTP
26802462680815570putative phage terminase small subunitQuickGO ontologyBLASTP
26810202681157138hypothetical protein
26813872681866480hypothetical proteinBLASTP
268186826832381371SNF2 domain proteinQuickGO ontologyBLASTP
26832412683408168hypothetical proteinBLASTP
26834012683589189VRR-NUC domain proteinQuickGO ontologyBLASTP
268394826863712424virulence-associated E domain proteinQuickGO ontologyBLASTP
268641726874421026hypothetical proteinBLASTP
26874802687710231glutamate racemaseQuickGO ontologyBLASTP
268774926897161968DNA polymeraseQuickGO ontologyBLASTP
26897222690342621conserved phage-associated proteinQuickGO ontologyBLASTP
269035426914991146conserved phage-associated proteinQuickGO ontologyBLASTP
26914992691948450hypothetical proteinBLASTP
26919822692236255hypothetical proteinBLASTP
26922362692487252hypothetical proteinBLASTP
26925062692859354hypothetical protein
26929232693474552RNA polymerase sigma factor sigma-70 familyQuickGO ontologyBLASTP
26936792693837159hypothetical proteinBLASTP
26938502694623774Gp26 proteinQuickGO ontologyBLASTP
26946842694827144hypothetical proteinBLASTP
26949282695128201hypothetical proteinBLASTP
26954202695794375DNA-binding proteinQuickGO ontologyBLASTP
269579826973361539resolvase family proteinQuickGO ontologyBLASTP
269746126986061146tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidAQuickGO ontologyBLASTP
269865727000871431adenylosuccinate lyaseQuickGO ontologyBLASTP
27003252700546222hypothetical proteinBLASTP
27005742700831258phosphocarrier protein HPrQuickGO ontologyBLASTP
270094227021351194aspartate aminotransferaseQuickGO ontologyBLASTP
27022802702636357multidrug resistance protein SMR familyQuickGO ontologyBLASTP
270263327039161284hypothetical proteinBLASTP
27039352704801867prenyltransferase UbiA familyQuickGO ontologyBLASTP
27049642705224261stage V sporulation protein SQuickGO ontologyBLASTP
270536327069041542HDIGHDKH domain proteinQuickGO ontologyBLASTP
270713927082061068recA proteinQuickGO ontologyBLASTP
27083452708929585CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
270891327102501338RNA modification enzyme MiaB familyQuickGO ontologyBLASTP
271034527126212277DNA translocase FtsKSpoIIIEQuickGO ontologyBLASTP
27131022713794693Clp protease family proteinQuickGO ontologyBLASTP
271404227152471206aspartokinase IQuickGO ontologyBLASTP
27152632715535273PRC-barrel domain proteinQuickGO ontologyBLASTP
271561227169131302peptidase M16 familyQuickGO ontologyBLASTP
271708727191952109polyribonucleotide nucleotidyltransferaseQuickGO ontologyBLASTP
27194592719773315ribosomal protein S15QuickGO ontologyBLASTP
27198552720775921riboflavin biosynthesis protein RibFQuickGO ontologyBLASTP