Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:2511035 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
251103525123121278tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidAQuickGO ontologyBLASTP
251236725137971431adenylosuccinate lyaseQuickGO ontologyBLASTP
25140352514256222hypothetical proteinBLASTP
25142842514541258phosphocarrier protein HPrQuickGO ontologyBLASTP
251465225158451194aspartate aminotransferaseQuickGO ontologyBLASTP
25159902516346357hypothetical proteinBLASTP
251634325176261284hypothetical proteinBLASTP
25176452518511867prenyltransferase UbiA familyQuickGO ontologyBLASTP
25186742518934261stage V sporulation protein SQuickGO ontologyBLASTP
251907325206141542HDIGHDKH domain proteinQuickGO ontologyBLASTP
252084925219161068recA proteinQuickGO ontologyBLASTP
25220552522639585CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
252262325239601338RNA modification enzyme MiaB familyQuickGO ontologyBLASTP
252405525263312277DNA translocase FtsKSpoIIIEQuickGO ontologyBLASTP
25268132527505693clp proteaseQuickGO ontologyBLASTP
252775325289581206aspartokinase IQuickGO ontologyBLASTP
25289742529246273PRC-barrel domain proteinQuickGO ontologyBLASTP
252932325306241302peptidase M16 familyQuickGO ontologyBLASTP
253079925329072109polyribonucleotide nucleotidyltransferaseQuickGO ontologyBLASTP
25331712533485315ribosomal protein S15QuickGO ontologyBLASTP
25335672534487921riboflavin biosynthesis protein RibFQuickGO ontologyBLASTP
25345002535369870tRNA pseudouridine synthase BQuickGO ontologyBLASTP
25353702536332963DHH family proteinQuickGO ontologyBLASTP
25363222536684363ribosome-binding factor AQuickGO ontologyBLASTP
253671525387812067translation initiation factor IF-2QuickGO ontologyBLASTP
25387992539116318ribosomal protein L7Ae family proteinQuickGO ontologyBLASTP
25391032539375273hypothetical proteinBLASTP
253943525408081374N utilization substance protein AQuickGO ontologyBLASTP
25408252541286462hypothetical proteinBLASTP
254159125458894299DNA polymerase III alpha subunit Gram-positive typeQuickGO ontologyBLASTP