Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_016913: Rickettsia rickettsii str. Brazil chromosome, complete genome

NCBI: NC_016913

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
124000*4610422105Island text1.5013113.247825.0396Neighbours21BLASTN24000.gbk
283988*10618122194Island text1.685311.776521.8845Neighbours21BLASTN+83988.gbk
3232500*25709924600Island text2.0719814.706228.554Neighbours21BLASTN+232500.gbk
4859931*89265432724Island text1.5055213.33925.8375Neighbours21BLASTN+859931.gbk
591750093787320374Island text1.8007812.989421.781Neighbours21BLASTN+917500.gbk
6974212*99529421083Island text1.5610216.32322.5111Neighbours21BLASTN974212.gbk
71066790*109021023421Island text1.61311.591115.7327Neighbours21BLASTN+1066790.gbk
81134000*115609922100Island text3.0393112.04125.941Neighbours21BLASTN+1134000.gbk