Pre_GI Gene

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Host: NC_016913 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016913:917500 Rickettsia rickettsii str. Brazil chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
917648917989342hypothetical proteinBLASTP
918130918408279hypothetical proteinBLASTP
9191589206511494endopeptidaseQuickGO ontologyBLASTP
9207139225961884molecular chaperone DnaKQuickGO ontologyBLASTP
9227259238461122chaperone protein DnaJQuickGO ontologyBLASTP
923925924026102hypothetical proteinBLASTP
92401692410893cation transport regulatorQuickGO ontologyBLASTP
924387925142756ComL family lipoproteinQuickGO ontologyBLASTP
9251509267871638DNA repair protein RecNQuickGO ontologyBLASTP
9268539283431491thermostable carboxypeptidaseQuickGO ontologyBLASTP
92847993126527872-oxoglutarate dehydrogenase E1 componentQuickGO ontologyBLASTP
931262931414153hypothetical proteinBLASTP
9314299326161188dihydrolipoamide succinyltransferaseQuickGO ontologyBLASTP
9327879332034176-carboxy-5678-tetrahydropterin synthaseQuickGO ontologyBLASTP
933206933520315divalent cation tolerance proteinQuickGO ontologyBLASTP
9335599347581200protonsodium-glutamate symport proteinQuickGO ontologyBLASTP
934812934997186hypothetical proteinBLASTP
935322935504183hypothetical proteinBLASTP
935915936046132hypothetical proteinBLASTP
936108936449342ankyrin repeat-containing proteinQuickGO ontologyBLASTP
936479936598120hypothetical proteinBLASTP
9366719378731203coproporphyrinogen III oxidaseQuickGO ontologyBLASTP