Pre_GI Gene

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Host: NC_016913 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016913:1066790 Rickettsia rickettsii str. Brazil chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
106679010681871398NADp transhydrogenase subunit betaQuickGO ontologyBLASTP
10682421068802561putative cytoplasmic proteinQuickGO ontologyBLASTP
106911910699408227-cyano-7-deazaguanine reductaseQuickGO ontologyBLASTP
10699441070657714cell cycle transcriptional regulatorQuickGO ontologyBLASTP
10708791071337459preprotein translocase subunit SecBQuickGO ontologyBLASTP
10713831071949567deoxycytidine triphosphate deaminaseQuickGO ontologyBLASTP
107223010735461317hypothetical proteinBLASTP
10739491074062114hypothetical protein
1074155107425399hypothetical protein
107424210764582217DNA topoisomerase IV subunit AQuickGO ontologyBLASTP
10766261077300675hypothetical proteinBLASTP
107747310792031731arginyl-tRNA synthetaseQuickGO ontologyBLASTP
107931710804711155deoxyguanosinetriphosphate triphosphohydrolase-like proteinQuickGO ontologyBLASTP
10806891081021333HesB protein family proteinQuickGO ontologyBLASTP
10811191081259141hypothetical proteinBLASTP
10816331081857225hypothetical proteinBLASTP
108266510834898252-dehydro-3-deoxyphosphooctonate aldolaseQuickGO ontologyBLASTP
10835251083842318hypothetical proteinBLASTP
108384510855121668putative ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
10857461086606861chromosome partitioning proteinQuickGO ontologyBLASTP
10865931087360768chromosome partitioning proteinQuickGO ontologyBLASTP
1087357108793557916S rRNA methyltransferase GidBQuickGO ontologyBLASTP
108791610897841869tRNA uridine 5-carboxymethylaminomethyl modification protein GidAQuickGO ontologyBLASTP
10897881090210423mulitfunctional nucleoside diphosphate kinaseapyrimidinic endonuclease3-phosphodiesteraseQuickGO ontologyBLASTP