Pre_GI Gene

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Host: NC_016913 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016913:83988 Rickettsia rickettsii str. Brazil chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
83988850281041rod shape-determining protein MreBQuickGO ontologyBLASTP
8503185870840rod shape-determining protein MreCQuickGO ontologyBLASTP
8622286458237hypothetical proteinBLASTP
8659987288690guanylate kinaseQuickGO ontologyBLASTP
87358885121155putative ATPaseQuickGO ontologyBLASTP
8854088770231hypothetical proteinBLASTP
88788898581071hypothetical proteinBLASTP
89935917161782ABC transporter ATP-binding protein uupQuickGO ontologyBLASTP
919989328412873-oxoacyl-acyl carrier protein synthase IIQuickGO ontologyBLASTP
9331893563246acyl carrier proteinQuickGO ontologyBLASTP
93742944677263-ketoacyl-ACP reductaseQuickGO ontologyBLASTP
94460954911032recombinase AQuickGO ontologyBLASTP
9623996466228hypothetical proteinBLASTP
9658496847264multidrug resistance protein BQuickGO ontologyBLASTP
97957992581302hypothetical proteinBLASTP
996511009881338tRNA modification GTPase TrmEQuickGO ontologyBLASTP
1010701058244755NAD-specific glutamate dehydrogenaseQuickGO ontologyBLASTP
105828106181354transcriptional regulatorQuickGO ontologyBLASTP