Pre_GI Gene

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Host: NC_016913 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016913:974212 Rickettsia rickettsii str. Brazil chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
974212974646435hypothetical proteinBLASTP
974729975529801chromosome partitioning ATPaseQuickGO ontologyBLASTP
9757489772501503multifunctional aminopeptidase AQuickGO ontologyBLASTP
9774149786011188hypothetical proteinBLASTP
9790029831204119DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP
9833789874994122DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP
98844698882638150S ribosomal protein L7L12QuickGO ontologyBLASTP
98902198953051050S ribosomal protein L10QuickGO ontologyBLASTP
98964199036072050S ribosomal protein L1QuickGO ontologyBLASTP
99036699080343850S ribosomal protein L11QuickGO ontologyBLASTP
991072991650579transcription antitermination protein NusGQuickGO ontologyBLASTP
991666991866201preprotein translocase subunit SecEQuickGO ontologyBLASTP
99206599214076tRNA-TrpQuickGO ontology
9922849943832100elongation factor GQuickGO ontologyBLASTP
99439699487848330S ribosomal protein S7QuickGO ontologyBLASTP
99490599529439030S ribosomal protein S12QuickGO ontologyBLASTP