Pre_GI Gene

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Host: NC_016913 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016913:24000 Rickettsia rickettsii str. Brazil chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24367257041338dimethylallyladenosine tRNA methylthiotransferaseQuickGO ontologyBLASTP
25708280802373multimodular transpeptidase-transglycosylase PBP 1AQuickGO ontologyBLASTP
2835928631273beta-lactamaseQuickGO ontologyBLASTP
2877029072303beta-lactamase OXA-18QuickGO ontologyBLASTP
2933129447117hypothetical protein
3040630834429ferroxidaseQuickGO ontologyBLASTP
30989323681380dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
3253233086555F0F1 ATP synthase subunit deltaQuickGO ontologyBLASTP
33252347841533F0F1 ATP synthase subunit alphaQuickGO ontologyBLASTP
3491835889972F0F1 ATP synthase subunit gammaQuickGO ontologyBLASTP
36062374831422F0F1 ATP synthase subunit betaQuickGO ontologyBLASTP
3754137879339F0F1 ATP synthase subunit epsilonQuickGO ontologyBLASTP
38061406972637aconitate hydrataseQuickGO ontologyBLASTP
4086641222357hypothetical proteinBLASTP
41225432402016NADH dehydrogenase subunit GQuickGO ontologyBLASTP
43362443811020NADHubiquinone oxidoreductase subunit HQuickGO ontologyBLASTP
4456845047480NADH dehydrogenase subunit IQuickGO ontologyBLASTP
4552946104576cytochrome c biogenesis protein CcmAQuickGO ontologyBLASTP