Pre_GI Gene

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Host: NC_016913 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016913:1134000 Rickettsia rickettsii str. Brazil chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11340141134223210hypothetical proteinBLASTP
113434611359501605methyltransferaseQuickGO ontologyBLASTP
11361971136718522transcriptional regulatorQuickGO ontologyBLASTP
11368821137715834protein-disulfide isomeraseQuickGO ontologyBLASTP
11378261138089264hypothetical proteinBLASTP
11380941138822729F0F1 ATP synthase subunit AQuickGO ontologyBLASTP
11390181139242225F0F1 ATP synthase subunit CQuickGO ontologyBLASTP
11392611139734474F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
11397341140228495F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
11405681140750183hypothetical proteinBLASTP
11408911141124234hypothetical proteinBLASTP
11410911141831741hypothetical proteinBLASTP
11422761142401126hypothetical proteinBLASTP
11427631142867105hypothetical proteinBLASTP
114314911486625514cell surface antigenQuickGO ontologyBLASTP
11493921149538147hypothetical proteinBLASTP
11495501150287738DNA translocation competence proteinQuickGO ontologyBLASTP
11503901150596207hypothetical proteinBLASTP
115108611523961311polyA polymeraseQuickGO ontologyBLASTP
11526421153346705zincmanganese ABC transporter substrate binding proteinQuickGO ontologyBLASTP
11533341153861528ATPGTP hydrolaseQuickGO ontologyBLASTP
11538691154024156hypothetical proteinBLASTP
11541101155033924hypothetical proteinBLASTP
11550511156046996tRNA-dihydrouridine synthaseQuickGO ontologyBLASTP