Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_016909: Rickettsia rickettsii str. Arizona chromosome, complete genome

NCBI: NC_016909

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
1164653609519631Island text2.5871311.712725.2954Neighbours21BLASTN16465.gbk
2100000*12209922100Island text2.1353911.004423.6082Neighbours21BLASTN+100000.gbk
3171018*19006319046Island text1.5261112.791726.5448Neighbours21BLASTN171018.gbk
423000025009920100Island text1.7139512.436121.2466Neighbours21BLASTN+230000.gbk
5278327*29617617850Island text1.47814.032123.7301Neighbours21BLASTN+278327.gbk
6563727*58643122705Island text1.4274315.229828.3591Neighbours21BLASTN563727.gbk
7771542*79409922558Island text1.7715511.235424.1442Neighbours21BLASTN+771542.gbk
8926000*95466828669Island text2.0932514.735628.4728Neighbours21BLASTN+926000.gbk
91136210115488318674Island text1.5035315.497325.332BLASTN1136210.gbk