Pre_GI Gene

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Host: NC_016909 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016909:278327 Rickettsia rickettsii str. Arizona chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2783272810442718DNA gyrase subunit AQuickGO ontologyBLASTP
281867282109243transporterQuickGO ontologyBLASTP
282081282371291transporterQuickGO ontologyBLASTP
282416282700285hypothetical proteinBLASTP
282821282940120hypothetical proteinBLASTP
283062283247186hypothetical proteinBLASTP
283274283426153hypothetical proteinBLASTP
283383283490108hypothetical proteinBLASTP
283698284225528peptide deformylaseQuickGO ontologyBLASTP
284222285133912methionyl-tRNA formyltransferaseQuickGO ontologyBLASTP
285350285793444hypothetical proteinBLASTP
289575290141567hypothetical proteinBLASTP
2903002913521053ATPaseQuickGO ontologyBLASTP
2915672926641098S-adenosylmethionine--tRNA ribosyltransferase-isomeraseQuickGO ontologyBLASTP
292831293259429hypothetical proteinBLASTP
293430293669240hypothetical proteinBLASTP
293753293887135hypothetical proteinBLASTP
2939552957241770multidrug ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
295904296176273hypothetical proteinBLASTP