Pre_GI Gene

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Host: NC_016909 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016909:563727 Rickettsia rickettsii str. Arizona chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
563727564056330acriflavin resistance plasma membrane proteinQuickGO ontologyBLASTP
564226564357132acriflavin resistance plasma membrane proteinQuickGO ontologyBLASTP
565622565798177acriflavin resistance periplasmic proteinQuickGO ontologyBLASTP
5671765681951020glycosyltransferaseQuickGO ontologyBLASTP
568199568486288hypothetical proteinBLASTP
568515568757243hypothetical proteinBLASTP
568924569085162hypothetical proteinBLASTP
569174569986813diaminopimelate epimeraseQuickGO ontologyBLASTP
5699615712261266tRNA 2-methylthioadenosine synthase-like proteinQuickGO ontologyBLASTP
5714695725181050phenylalanyl-tRNA synthetase subunit alphaQuickGO ontologyBLASTP
5725155749712457phenylalanyl-tRNA synthetase subunit betaQuickGO ontologyBLASTP
5749765761151140DNA polymerase III subunit betaQuickGO ontologyBLASTP
576121576243123DnaJ family molecular chaperoneQuickGO ontologyBLASTP
576209576313105DnaJ family molecular chaperoneQuickGO ontologyBLASTP
576470576973504hypothetical proteinBLASTP
5771025796092508leucyl-tRNA synthetaseQuickGO ontologyBLASTP
580128580259132hypothetical proteinBLASTP
580686581297612ribonuclease DQuickGO ontologyBLASTP
581446581751306septum formation initiatorQuickGO ontologyBLASTP
581748582440693phosphatidate cytidylyltransferaseQuickGO ontologyBLASTP
582400583080681undecaprenyl pyrophosphate synthetaseQuickGO ontologyBLASTP
5832535846831431osmolarity sensor protein EnvZQuickGO ontologyBLASTP
584667585347681transcriptional regulatorQuickGO ontologyBLASTP
585559586431873branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP