Pre_GI Gene

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Host: NC_016909 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016909:171018 Rickettsia rickettsii str. Arizona chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1710181728081791succinate dehydrogenase flavoprotein subunitQuickGO ontologyBLASTP
172955173611657hypothetical proteinBLASTP
17377017415939030S ribosomal protein S12QuickGO ontologyBLASTP
17418617466848330S ribosomal protein S7QuickGO ontologyBLASTP
1746811767802100elongation factor GQuickGO ontologyBLASTP
17692417699976tRNA-TrpQuickGO ontology
177198177398201preprotein translocase subunit SecEQuickGO ontologyBLASTP
177414177992579transcription antitermination protein NusGQuickGO ontologyBLASTP
17826217869943850S ribosomal protein L11QuickGO ontologyBLASTP
17870517942472050S ribosomal protein L1QuickGO ontologyBLASTP
17953518004451050S ribosomal protein L10QuickGO ontologyBLASTP
18023918061938150S ribosomal protein L7L12QuickGO ontologyBLASTP
1815661856874122DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP
1859451900634119DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP